Oxaliplatin

Overview
Catalog #	bs-75501c-5mg
Product Name	Oxaliplatin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 61825-94-3 Molecular formula: C8H14N2O4Pt Molecular weight: 397.3 Purity: >98% (1H-NMR) Appearance: White to off-white powder. Solubility: Soluble in DMSO (20mg/ml)* or water (2mg/ml). Slightly soluble in methanol. Insoluble in ethanol. InChiKey: ZROHGHOFXNOHSO-USPAICOZSA-L SMILES: O=C1O[Pt]2(N[C@H]3CCCC[C@@H]3N2)OC1=O
Description	Potent platinum-based antineoplastic agent with wide spectrum anticancer activity [2, 7-9]. Anticancer compound. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death [1, 4, 7, 10, 13]. Shows antitumor activity in cisplatin resistant cell lines [3, 8]. Shows better biochemical, pharmacological and cytotoxic properties than cisplatin (Prod. No. bs-75499C) and carboplatin (Prod. No. bs-75500C) [5, 7, 8]. Apoptosis inducer [10, 11]. Targets other proteins and enzymes [6]. Anticancer activity and antitumor specificity depends on selective uptake through human organic cation transporters 1 (OCT1) and OCT2 [12]. Neurotoxic profile depends on organic cation transporter 2 (OCT2) uptake [14].