Etoposide

Overview
Catalog #	bs-75483c-25mg
Product Name	Etoposide
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +20°C. Store solutions in DMSO at 4°C. After reconstitution, prepare aliquots and store at -20°C.
Target
Product Information	CAS Number: 33419-42-0 Molecular formula: C29H32O13 Molecular weight: 588.6 Purity: >98% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in DMSO, ethanol, methanol or dimethylformamide. InChiKey: VJJPUSNTGOMMGY-MRVIYFEKSA-N SMILES: [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=C(C=C3OCOC3=C1)[C@H]2O[C@]1([H])O[C@]2([H])CO[C@@H](C)O[C@@]2([H])[C@H](O)[C@H]1O
Description	Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines [1, 5]. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication [2, 4, 6]. p53 activator [3]. Blocks the cell cycle between the end of the S phase and the early G2 phase [2, 8]. Oncoprotein Mdm2 synthesis inhibitor [7]. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway [9, 10]. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcription and alternative splicing) [11, 14, 15]. Chemotherapeutic compound used in cancers [12, 13]. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation [16]. Highly effective in mobilizing stem cells [17]