Colcemid

Overview
Catalog #	bs-75478c-1mg
Product Name	Colcemid
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 477-30-5 Molecular formula: C21H25NO5 Molecular weight: 371.4 Purity: >98% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in ethanol, DMSO or chloroform. InChiKey: NNJPGOLRFBJNIW-HNNXBMFYSA-N SMILES: O=C1C(OC)=CC=C(C([C@@H](NC)CC2)=C1)C3=C2C=C(OC)C(OC)=C3OC
Description	Anti-cancer compound [2, 6, 7, 10, 11, 14]. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle [11, 12, 14]. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 4, 5, 14]. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation [2, 5, 7, 8, 14]. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center [14]. Apoptosis inducer [9, 13]. Thrombopoietic agent [3].