WY-14643

Overview
Catalog #	bs-75477c-10mg
Product Name	WY-14643
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 50892-23-4 Molecular formula: C14H14ClN3O2S Molecular weight: 323.8 Purity: >98% Appearance: Off-white solid. Solubility: Soluble in ethanol, DMSO, dimethyl formamide or PBS (pH 7.2). InChiKey: NSHPHXHGRHSMIK-WAXGXQFOSA-N SMILES: CC1=CC=CC(NC2=NC(SCC(O)=O)=NC(Cl)=C2)=C1C
Description	Potent peroxisome proliferator-activated receptor (PPARalpha) activator [1, 2, 7, 9]. Activates also PPARgamma [4, 7] but not PPARdelta [8]. Potent anti-hypercholesterolemic agent [1]. Hypolipidemic compound. Lipogenesis inducer [2, 10]. Tumor promoter [2, 3, 5, 15]. Causes increased cell proliferation and decreased apoptosis [5]. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress [6, 7, 12, 13]. Increases fatty acid oxidation [11]. Directly affects insulin signaling. Increases glucose uptake [12]. Enhancer of ethanol metabolism. Reviews [5, 11, 14].