IHR-1

Overview
Catalog #	bs-75451c-1mg
Product Name	IHR-1
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C.
Target
Product Information	CAS Number: 548779-60-8 Molecular formula: C20H12Cl4N2O2 Molecular weight: 454.1 Purity: >98% (NMR) Appearance: White to grey solid. Solubility: Soluble in DMSO. InChiKey: VCLHHRGZKNUOAQ-UHFFFAOYSA-N SMILES: ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1
Description	Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.