TOFA
Overview | |
Catalog # | bs-75425c-5mg |
Product Name | TOFA |
Specifications | |
Storage Buffer | Solid |
Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
Target | |
Product Information | CAS Number: 54857-86-2 Molecular formula: C19H32O4 Molecular weight: 324.5 Purity: >98% Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml), DMF (5mg/ml) or ethanol (5mg/ml). InChiKey: CZRCFAOMWRAFIC-UHFFFAOYSA-N SMILES: CCCCCCCCCCCCCCOC1=CC=C(C(O)=O)O1 |
Description | Fatty acid synthase (FASN) inhibitor. Cell permeable, potent, reversible and competitive inhibitor of acetyl-CoA carboxylase (ACC) consequently blocking the synthesis of malonyl-CoA. Useful agent for immunometabolism research. Anticancer agent. Induces apoptosis in a variety of tumor cell lines. Relatively non-cytotoxic to various cancer cell lines. TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (AG-CR1-2904) on food intake in fasted mice and on apoptosis in tumor cells. Hypolipidemic agent. Stimulates citrate accumulation in the cell, which leads to a suppression of glycolysis by citrate-induced inhibition of phosphofructokinase. |