Raptinal

Overview
Catalog #	bs-75423c-1mg
Product Name	Raptinal
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 1176-09-6 Molecular formula: C28H18O2 Molecular weight: 386.4 Purity: >98% (NMR) Appearance: Beige solid. Solubility: Soluble in DMSO. InChiKey: GLANOOJJBKXTMI-UHFFFAOYSA-N SMILES: O=CC1(C2(C=O)C3=C(C=CC=C3)C4=C2C=CC=C4)C5=C(C=CC=C5)C6=C1C=CC=C6
Description	Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.