Bisindolylmaleimide I . hydrochloride [GF-109203X; Gö 6850]
| Overview | |
| Catalog # | bs-75399c-1mg |
| Product Name | Bisindolylmaleimide I . hydrochloride [GF-109203X; Gö 6850] |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Target | |
| Product Information | CAS Number: 176504-36-2 Molecular formula: C25H24N4O2 . HCl Molecular weight: 412.5 . 36.5 Purity: >98% (NMR) Appearance: Orange to red powder. Solubility: Soluble in DMSO or methanol. Slightly soluble in water. InChiKey: XRAMWNCMYJHGGH-UHFFFAOYSA-N SMILES: Cl.CN(C)CCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2 |
| Description | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM) [1]. Competitive inhibitor for the ATP-binding site of PKC [1]. Anti-inflammatory [2]. Binds to P-glycoprotein [3]. Telomerase activity inhibitor [4]. Potent glycogen synthase kinase-3 (GSK-3) inhibitor [5]. Necrosis inhibitor [6]. Blocks hERG potassium channels [7-9]. Promotes osteoblastogenesis in human mesenchymal stem cells [10]. |
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