Splitomicin

Overview
Catalog #	bs-75395c-1mg
Product Name	Splitomicin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 5690-03-9 Molecular formula: C13H10O2 Molecular weight: 198.2 Purity: >98% (NMR) Appearance: White to off-white solid. Solubility: Soluble in methanol, ethanol or DMSO. InChiKey: ISFPDBUKMJDAJH-UHFFFAOYSA-N SMILES: O=C1CCC2=C(O1)C=CC1=CC=CC=C21
Description	Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4]. Displays higher activity in vivo than in vitro [1-4]. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5]. Shown to have diverse effects also in mammalian cells [6-10].