DAPT

Overview
Catalog #	bs-75350c-5mg
Product Name	DAPT
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 208255-80-5 Molecular formula: C23H26F2N2O4 Molecular weight: 432.5 Purity: >98% (NMR) Appearance: White to off-white solid. Solubility: Soluble in 100% ethanol, DMSO (20 mg/ml) or dichloromethane. InChiKey: DWJXYEABWRJFSP-XOBRGWDASA-N SMILES: C[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H](C(=O)OC(C)(C)C)C1=CC=CC=C1
Description	Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42) [1]. Reduces Abeta levels in vivo [2]. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD) [3]. Does not inhibit persenilinase [4]. Notch processing inhibitor [5]. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling [6]. CDK5 activity inhibitor [7]. Apoptosis enhancer [8]. Inhibitor of slurp-like1 expression in the floor plate of the neural tube.