Z-Phe-Arg-AFC

Overview
Catalog #	bs-75312c-5mg
Product Name	Z-Phe-Arg-AFC
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C.
Target
Product Information	CAS Number: 93753-73-2 (free base) Molecular formula: C33H33F3N6O6 . C2HF3O2 Molecular weight: 666.7 . 114.0 Purity: >95% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO. Moderately soluble and highly stable in water-based solvents. InChiKey: FLPBOIDNDJASFK-CCQIZPNASA-N SMILES: [NH3+]C(NCCC[C@@H](C(NC1=CC=C(C(C(F)(F)F)=CC(O2)=O)C2=C1)=O)NC([C@H](CC3=CC=CC=C3)NC(OCC4=CC=CC=C4)=O)=O)=N.FC(F)(C([O-])=O)F
Description	Fluorogenic substrate, specifically used to determine the enzyme activity of Cathepsin L. Useful for the study of cathepsin activity and for screening small molecule inhibitors for drug discovery and HTS applications. Likely to be cleaved by cathepsins B, F, K, S and L, cathepsins L-like proteases and proteases such as papain, cruzipain, plasma kallikrein, soybean trypsin-like enzyme and the falcipains-1 and -2 (malaria hemoglobinases). Hydrolysis of this substrate is monitored by observing fluorescence at an Excitation of 400nm and Emission at 505nm.