BQ-123 . sodium salt

Overview
Catalog #	bs-75288c-1mg
Product Name	BQ-123 . sodium salt
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 3 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 136655-57-7; 136553-81-6 (free base) Molecular formula: C31H42N6O7 . Na Molecular weight: 609.7 . 23.0 Purity: >98% (HPLC) Appearance: White solid. Solubility: Soluble in water. InChiKey: FLIKEIGEOXCRRG-DRBUQPBJSA-M SMILES: [Na+].CC(C)CC1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC([O-])=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C
Description	Potent and selective endothelin receptor A (ETA) antagonist [1-3]. Suppresses the ET-1-induced decrease of LPL activity [4]. Shows protective effects in ischemic acute renal failure [5]. Neuroprotective [6, 10]. Anti-hypertensive [7]. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation [8]. Cardiovascular agent [9]. Reduces myocardial infarct size and oxidant injury [11]. Selected Reviews [12, 13].