Simvastatin . sodium salt

Overview
Catalog #	bs-75282c-5mg
Product Name	Simvastatin . sodium salt
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 101314-97-0 Molecular formula: C25H39O6 . Na Molecular weight: 435.6 . 23.0 Purity: >98% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in water (30mg/ml). Soluble in DMSO, ethanol or DMF (all 10mg/ml). InChiKey: RLWRROYWKHUVKF-OKDJMAGBSA-M SMILES: C[C@@H]1C[C@H](OC(C(CC)(C)C)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[Na+]
Description	Synthetic analog of Lovastatin (Prod. No. bs-75050C). Water-soluble carboxylate form of Simvastatin (Prod.No. bs-75051C). Potent competitive HMG-CoA reductase inhibitor [1]. Anti-hypercholesterolemic agent [1]. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids [1, 2]. Inhibits the isoprenylation of Ras and Rho family GTPases [2]. Smooth muscle cell proliferation inhibitor [3]. Anti-adhesive, immunomodulatory and anti-inflammatory compound [4, 7, 10]. Proteasome modulator [5]. Stimulates bone formation [6]. Apoptosis inducer [8]. Anticancer compound [8, 9]. Increases cellular resistance to anticancer agents such as doxorubicin and etoposides (Prod. No. bs-75483C) [9]. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection [11, 12]. Anti-hypertensive agent [13]. Suppresses TNF-induced NF-kappaB activation [14].