Fumagillin

Overview
Catalog #	bs-75274c-1mg
Product Name	Fumagillin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 23110-15-8 Molecular formula: C26H34O7 Molecular weight: 458.6 Purity: >98% (1H-NMR) Appearance: Off-white solid. Solubility: Soluble in DMSO, acetone or chloroform. Slightly soluble in methanol (5mg/ml) or ethanol. Insoluble in water. InChiKey: NGGMYCMLYOUNGM-IWMBURASSA-N SMILES: [H][C@@]1([C@H](OC)[C@@H](CC[C@]11CO1)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)[C@@]1(C)O[C@@H]1CC=C(C)C
Description	Meroterpenoid antibiotic. Anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Suppresses the HIV-1 infection of human macrophages through the inhibition of HIV-1 viral protein R (Vpr) activity. Inhibits neovascularization and might be useful in non-tumor diseases such as diabetic retinopathy, arthritis and psoriasis, which involve neovascularisation processes. Reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.