Sipholenone A

Overview
Catalog #	bs-75262c-100ug
Product Name	Sipholenone A
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 78518-74-8 Molecular formula: C30H50O4 Molecular weight: 474.7 Purity: >98% (HPLC) Appearance: White to off-white lyophilized powder. Solubility: Soluble in DMSO or 100% ethanol (25mg/ml). InChiKey: LKZQMXLIWZQEEU-KOGSSWOMSA-N SMILES: CC(O1)(C)C(CC[C@@]2(C)[C@@]1([H])CC[C@@](O)(C)[C@@H]2CC[C@@H]3C(C)(C)[C@@](CC[C@@]4(C)O)([H])[C@@]4([H])CC=C3C)=O
Description	Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell. Reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Potentiates the cytotoxicity of established Pgp substrates such as colchicine, vinblastine and paclitaxel. Antiproliferative, antiangiogenic and cytotoxic compound. Moderate antifouling compound.