Salinosporamide A

Overview
Catalog #	bs-75213c-100ug
Product Name	Salinosporamide A
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C.
Target
Product Information	CAS Number: 437742-34-2 Molecular formula: C15H20ClNO4 Molecular weight: 313.8 Purity: >95% (HPLC) Appearance: White solid. Solubility: Soluble in DMSO. Do not dissolve in methanol or ethanol. InChiKey: NGWSFRIPKNWYAO-SHTIJGAHSA-N SMILES: [H][C@](O)([C@@]1([H])CCCC=C1)[C@@]12NC(=O)[C@H](CCCl)[C@]1(C)OC2=O
Description	Potent, irreversible inhibitor of all the 3 proteolytic activities of the mammalian 20S proteasome. beta5 subunit: chymotrypsin-like (EC50 = 3.5nM) beta2 subunit: trypsin-like (EC50 = 28nM) beta1 subunit: caspase-like or peptidyl-glutamyl peptide-hydrolyzing (PGPH) (EC50 = 430nM) Potent anticancer compound. Triggers apoptosis, with distinct proteasome activity and mechanism of action compared to bortezomib (Velcade) (Prod. No. bs-75509C). Most potent suppressor of NF-kappaB activation, compared with bortezomib, MG-132 (Prod. No. bs-75297C), N-acetyl-leucyl-leucyl-norleucinal (ALLN) and lactacystin (Prod. No. bs-75086C). Inhibitor of TNF-alpha, IL-1, IL-6, ICAM-1 and VEGF synthesis. Displays a longer inhibition duration than bortezomib. Potent antileukemic activity against bortezomib-resistant leukemia cells.