Ophiobolin A

Overview
Catalog #	bs-75208c-100ug
Product Name	Ophiobolin A
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 4611-05-6 Molecular formula: C25H36O4 Molecular weight: 400.6 Purity: >95% (HPLC) Appearance: White solid. Solubility: Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in water. InChiKey: MWYYLZRWWNBROW-BDZRSQQBSA-N SMILES: [H]C(=O)C1=C[C@]2([H])[C@](C)(CC[C@@]22O[C@H](C[C@@H]2C)C=C(C)C)C[C@@]2([H])[C@]1([H])C(=O)C[C@@]2(C)O
Description	Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase [1-3, 5, 6, 9]. Herbicidal mycotoxin [7]. Phytotoxic, antifungal, antibacterial and nematocidal compound [4, 6, 10]. Anticancer compound. Shown to induce paraptosis-like cell death [11, 12]. Shown to inhibit P-glycoprotein-mediated transport [8]. Disruptor of intracellular sulfhydryl proteostasis, leading to ER stress and dilation.