Calphostin C

Overview
Catalog #	bs-75207c-100ug
Product Name	Calphostin C
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Target
Product Information	CAS Number: 121263-19-2 Molecular formula: C44H38O14 Molecular weight: 790.8 Purity: >95% (HPLC) Appearance: Dark red to brown solid. Solubility: Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in water. InChiKey: SRJYZPCBWDVSGO-UHFFFAOYSA-N SMILES: COC1=C2C3=C(OC)C=C(O)C4=C3C(C(CC(C)OC(=O)C3=CC=CC=C3)=C(OC)C4=O)=C3C(CC(C)OC(=O)OC4=CC=C(O)C=C4)=C(OC)C(=O)C(C(O)=C1)=C23
Description	Potent and highly specific cell permeable protein kinase C (PKC) inhibitor [1]. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion