Ionomycin (free acid)

Overview
Catalog #	bs-75194c-1mg
Product Name	Ionomycin (free acid)
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 56092-81-0 Molecular formula: C41H72O9 Molecular weight: 709 Purity: >98% (HPLC, TLC) Appearance: Waxy yellow to colorless solid. Solubility: Soluble in methanol (2mg/ml), ethanol (10mg/ml) or DMSO (10mg/ml). InChiKey: PGHMRUGBZOYCAA-ZRDXXTDTSA-N SMILES: [H][C@@]1(CC[C@](C)(O1)[C@@H](C)O)[C@]1(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C\C[C@@H](C)C[C@@H](C)C(\O)=C\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O)O1
Description	Antibiotic [1]. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators [2, 3]. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+ [3, 9]. Apoptosis inducer [4, 7]. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination [6]. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA [5, 8]. ADAM10 agonist [10]. Potent inducer of shedding CXCL16 [10]. TREK-1 channels inhibitor [11]. PPARgamma ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes [12].