Lactacystin

Overview
Catalog #	bs-75086c-100ug
Product Name	Lactacystin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 3 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 133343-34-7 Molecular formula: C15H24N2O7S Molecular weight: 376.4 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in water (10mM), methanol, ethanol, DMSO, pyridine, acetonitrile or dimethyl formamide. Insoluble in hexane, benzene, chloroform or ethyl acetate. InChiKey: DAQAKHDKYAWHCG-MJZHQVMOSA-N SMILES: CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O
Description	Induces neuritogenesis [1, 3]. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex) [2, 4, 7]. Blocks proteasome activity by targeting the catalytic beta-subunit [5]. Apoptosis inducer [4, 6, 7, 10]. Anticancer compound [6, 10, 13]. Upregulates HSP70 and HSP22 [8]. Induces differentiation and inhibits cell cycle progression in several tumor cell lines [9]. Inhibits NF-kappaB activation by inhibiting IkappaB degradation [11]. Cathepsin A inhibitor [12]. beta-Secretase activity inhibitor [14]. Anti-adipogenic [15, 16]. Autophagy inducer [17].