K-252c

Overview
Catalog #	bs-75080c-1mg
Product Name	K-252c
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. Stock solutions are stable for 3 months when stored at -20°C.
Target
Product Information	CAS Number: 85753-43-1 Molecular formula: C20H13N3O Molecular weight: 311.4 Purity: >97% (HPLC) Appearance: Off-white to yellow crystalline solid. Solubility: Soluble in DMSO or methanol. Insoluble in water. InChiKey: MEXUTNIFSHFQRG-UHFFFAOYSA-N SMILES: O=C1NCC2=C1C1=C(NC3=C1C=CC=C3)C1=C2C2=C(N1)C=CC=C2
Description	Indolocarbazole alkaloid antibiotic. [1]. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A) [1-5]. Anticancer compound. Cytotoxic againt various cancer cell lines [6, 9,11]. Apoptosis inducer [11]. Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) [7]. LACTB (beta-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor [8]. Inhibits mixed lineage kinase (MLK) [10].