Cyclosporin A

Overview
Catalog #	bs-75070c-100mg
Product Name	Cyclosporin A
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 3 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 59865-13-3 Molecular formula: C62H111N11O12 Molecular weight: 1202.6 Purity: >98% Appearance: White solid. Solubility: Soluble in DMSO, ethanol, methanol, dichlormethane, chloroform or acetone. Insoluble in water. InChiKey: PMATZTZNYRCHOR-VPYFBNRVBI SMILES: [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C
Description	Potent immunosuppressant (same as FK-506 (Prod. No. bs-75046C) and rapamycin (Prod. No. bs-75027C)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits nitric oxide synthesis induced by interleukin-1alpha, lipopolysaccharides and TNF-alpha. Potently induces highly cardiogenic progenitors from embryonic stem (ES) cells.