Fostriecin

Overview
Catalog #	bs-75055c-10ug
Product Name	Fostriecin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 87860-39-7 Molecular formula: C19H26O9PNa Molecular weight: 452.4 Purity: >95% (HPLC) Appearance: Colorless solid. Solubility: Soluble in water, methanol or ethanol. InChiKey: XBUIKNRVGYFSHL-CZYWAGOEBB SMILES: [Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O
Description	Antibiotic [1, 2, 18]. Anticancer compound [1-5, 8, 9, 11]. Antifungal [6]. Catalytic inhibitor of topoisomerase II (IC50 = 40 µM) [7, 16]. Potent protein phosphatase 2A (PP2A) (IC50 = 1.5 nM) and 4 (PP4) (IC50 = 3 nM) inhibitor [10, 12, 15]. Weak protein phosphatase type 1 (PP1) inhibitor (IC50=131µM). No apparent inhibition on PP2B [10, 12]. Mitotic entry checkpoint inhibitor [10]. Mediates cell cycle arrest at G2-M-phase [14]. Ischemia protective [13]. The PP2A binding site is different from that of okadaic acid [17, 19]