Swinholide A

Overview
Catalog #	bs-75036c-50ug
Product Name	Swinholide A
Specifications
Storage Buffer	Oil
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 95927-67-6 Molecular formula: C78H132O20 Molecular weight: 1389.9 Purity: >98% (HPLC) Appearance: Colorless oil. Solubility: Soluble in ethanol, methanol, DMSO, acetone or ethyl acetate. InChiKey: RJVBVECTCMRNFG-VGHOFLFQSA-N SMILES: CO[C@@H]1C[C@H](C)O[C@@H](CC[C@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)\C=C\C(\C)=C\C[C@H](O)C[C@@H]3O[C@@H](CC=C3)C[C@H](OC)[C@@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@H](OC(=O)\C=C\C(\C)=C\C[C@H](O)C[C@H]3O[C@@H](CC=C3)C[C@H](OC)[C@@H](C)[C@@H](O)C[C@@H](O)[C@@H]2C)[C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]2C[C@@H](C[C@H](C)O2)OC)C1
Description	Cell permeable dimeric dilactone macrolide [1]. Cytotoxic compound [1, 2, 7]. Specific actin filament (F-actin) inhibitor. Disrupts the actin cytoskeleton by sequestering actin dimers and rapidly severing actin filaments (F-actin) [3, 5, 7, 8]. Depolymerizes actin filaments (F-actin) [6]. Antifungal [4]. Apoptosis inducer [9]. Alterates the actin cytoskeleton of GH4 cells and inhibits insulin-increased prolactin gene transcription [10].