Radicicol

Overview
Catalog #	bs-75023c-1mg
Product Name	Radicicol
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 12772-57-5 Molecular formula: C18H17ClO6 Molecular weight: 364.8 Purity: >99% (HPLC) Appearance: White to slightly yellow solid. Solubility: Soluble in DMSO, methanol, acetone, ethyl acetate or chloroform. InChiKey: WYZWZEOGROVVHK-HAJNAQHISA-N SMILES: [H][C@@]12C[C@@H](C)OC(=O)C3=C(O)C=C(O)C(Cl)=C3CC(=O)\C=C\C=C/[C@]1([H])O2
Description	Antibiotic [1]. Protein tyrosine kinase inhibitor [1]. Has antifungal [4], antimalarial [6], antiangiogenic (in vivo) [2], anti-inflammatory [5] and antiviral activity. Cyclooxygenase-2 (COX-2) expression inhibitor without affecting COX-1 expression in LPS-stimulated macrophages [3, 5]. Induces the differentiation of HL-60 cells into macrophages [4]. Potent HSP90 inhibitor [7, 9, 12]. Anticancer compound [7, 9, 12]. In vivo Rad/Raf interaction inhibitor [8]. Inhibitor of AP-1-, NF-kappaB- and serum response factor (SRF)-mediated transcription. Suppresses expression of iNOS (NOS II) [10]. Non-competitive inhibitor of ATP citrate lyase [11]. DNA topoisomerase VI and type II DNA topoisomerase inhibitor [13]. Protects against LPS/IFN-gamma-induced neuronal cell death [14]. Apoptosis inducer [16]. Pyruvate dehydrogenase kinase 3 (PDK3) inhibitor, by binding directly to the ATP-binding pocket [15].