Nigericin . sodium salt

Overview
Catalog #	bs-75022c-5mg
Product Name	Nigericin . sodium salt
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 28643-80-3 Molecular formula: C40H67O11 . Na Molecular weight: 724.0 . 23.0 Purity: >98% (TLC) Appearance: White to off-white powder. Solubility: Soluble in methanol, ethanol, dichlormethane or ethyl acetate. Insoluble in water. InChiKey: MOYOTUKECQMGHE-PDEFJWSRSA-M SMILES: [Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@H](C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C
Description	Antibiotic [1]. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+ [2, 3, 4, 7, 10]. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity [3, 6]. Disrupts membrane potential of mitochondria [2]. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release [5, 8, 11, 12]. Autophagy modulator [13]