Hyperforin . DCHA

Overview
Catalog #	bs-75014c-500ug
Product Name	Hyperforin . DCHA
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 238074-03-8 Molecular formula: C35H51O4 . C12H24N Molecular weight: 535.8 . 182.3 Purity: >97% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in 100% ethanol, methanol or DMSO. InChiKey: ZUYCAROZOLUHJY-DNSWOBEMSA-N SMILES: C1CCC(CC1)NC1CCCCC1.CC(C)C(=O)[C@@]12C(O)=C(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C2=O
Description	Key constituent of St. John's wort. Shows properties of potential pharmacological interest, including antibacterial [1], anti-malarial [13], anti-inflammatory [7, 14], anti-cancer and anti-angiogenic effects [5, 10]. Anti-depressant and anxiolytic compound [3]. Specific activator of TRPC6 channels [11]. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate) [4]. Activator of the pregnane X receptor (PXR) [2]. Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism [8]. Potential anti-Alzheimer compound [6, 9, 15]. Potent SIRT1 (sirtuin 1) and SIRT2 (sirtuin 2) inhibitor [12]. Based on the anti-inflammatory activity of Hyperforin and its simultaneous blockade of multiple signaling pathways, such as IFN‐gamma/IL‐1beta/TNF‐alpha, JAK/STAT, NF‐kappaB and MAPK it has been suggested a valuable agent for cytokine storm treatment during COVID-19 [16].