dBRD9-A

Overview
Catalog #	bs-7210c-2mg-solid
Product Name	dBRD9-A
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 779.88 Formula: C42 H49 N7 O8 CAS Number: 2170679-42-0 InChi Key: ZDINQSNMYRVAGP-UHFFFAOYSA-N InChi: InChI=1S/C42H49N7O8/c1-47(23-31-34(56-3)20-26(21-35(31)57-4)30-24-48(2)40(53)29-22-43-19-16-27(29)30)25-37(51)45-18-10-8-6-5-7-9-17-44-32-13-11-12-28-38(32)42(55)49(41(28)54)33-14-15-36(50)46-39(33)52/h11-13,16,19-22,24,33,44H,5-10,14-15,17-18,23,25H2,1-4H3,(H,45,51)(H,46,50,52) Smiles: CN(CC(=O)NCCCCCCCCNC1C=CC=C2C=1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1C(=CC(=CC=1OC)C1=CN(C)C(=O)C2=CN=CC=C12)OC Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	dBRD9-A is a potent BRD9 degrader that selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. It was shown to inhibit the growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.