ML277

Overview
Catalog #	bs-7123c-2mg-solid
Product Name	ML277
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 471.59 Formula: C23 H25 N3 O4 S2 CAS Number: 1401242-74-7 InChi Key: OXQNLLVUVDAEHC-OAQYLSRUSA-N InChi: InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1 Smiles: CC1C=CC(=CC=1)S(=O)(=O)N1CCCC[C@@H]1C(=O)NC1=NC(=CS1)C1C=CC(=CC=1)OC Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.