Capmatinib HCl hydrate

Overview
Catalog #	bs-7076c-10mg-solid
Product Name	Capmatinib HCl hydrate
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 503.36 Formula: C23 H21 Cl2 F N6 O2 CAS Number: 1865733-40-9 InChi Key: COWBUPJEEDYWKD-UHFFFAOYSA-N InChi: InChI=1S/C23H17FN6O.2ClH.H2O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;;;/h2-9,11-13H,10H2,1H3,(H,25,31);2*1H;1H2 Smiles: O.Cl.Cl.CNC(=O)C1C=CC(=CC=1F)C1C=NC2=NC=C(CC3C=C4C=CC=NC4=CC=3)N2N=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. Capmatinib was approved in 2020.