LC3-mHTT-IN-AN1
| Overview | |
| Catalog # | bs-6994c-10mg-solid |
| Product Name | LC3-mHTT-IN-AN1 |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 411.04 Formula: C15 H9 Br2 N O3 CAS Number: 486443-73-6 InChi Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N InChi: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3- Smiles: OC1=CC(/C=C2\C(=O)NC3=CC=C(Br)C=C3\2)=CC(Br)=C1O Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | LC3-mHTT-IN-AN1 is a HTT-LC3 linker compound. LC3-mHTT-IN-AN1 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. LC3-mHTT-IN-AN1 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease |
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