IACS-9571

Overview
Catalog #	bs-6962c-10mg-solid
Product Name	IACS-9571
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 642.76 Formula: C32 H42 N4 O8 S CAS Number: 1800477-30-8 InChi Key: HYQBRUSSCIAOOD-UHFFFAOYSA-N InChi: InChI=1S/C32H42N4O8S/c1-8-14-42-22-16-23(43-15-10-9-13-34(2)3)18-24(17-22)44-30-21-28-27(35(4)32(37)36(28)5)20-26(30)33-45(38,39)25-11-12-29(40-6)31(19-25)41-7/h11-12,16-21,33H,8-10,13-15H2,1-7H3 Smiles: CN(C)CCCCOC1C=C(C=C(C=1)OCCC)OC1=CC2=C(C=C1NS(=O)(=O)C1C=CC(OC)=C(C=1)OC)N(C)C(=O)N2C Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	IACS-9571 is a potent and selective inhibitor TRIM24 and BRPF1. IACS-9571 has low nanomolar affinities for TRIM24 and BRPF1 (ITC Kd = 31 nM and 14 nM, respectively). With its excellent cellular potency (EC50 = 50 nM) and favorable pharmacokinetic properties (F = 29%), IACS-9571 is a high-quality chemical probe for the evaluation of TRIM24 and/or BRPF1 bromodomain function in vitro and in vivo.