DK419

Overview
Catalog #	bs-6956c-10mg-solid
Product Name	DK419
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 407.7 Formula: C16 H8 Cl F6 N3 O CAS Number: 2102672-22-8 InChi Key: MWNNIGRGNSXNEA-UHFFFAOYSA-N InChi: InChI=1S/C16H8ClF6N3O/c17-8-5-10(12-11(6-8)25-14(26-12)16(21,22)23)13(27)24-9-3-1-7(2-4-9)15(18,19)20/h1-6H,(H,24,27)(H,25,26) Smiles: O=C(NC1C=CC(=CC=1)C(F)(F)F)C1=CC(Cl)=CC2NC(=NC=21)C(F)(F)F Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.