CHIR99021 HCl

Overview
Catalog #	bs-6931c-10mg-solid
Product Name	CHIR99021 HCl
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 501.8 Formula: C22 H19 Cl3 N8 CAS Number: 1797989-42-4 InChi Key: SCQDMKUZHIGAIB-UHFFFAOYSA-N InChi: InChI=1S/C22H18Cl2N8.ClH/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19;/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32);1H Smiles: Cl.CC1=CNC(=N1)C1=CN=C(NCCNC2C=CC(=CN=2)C#N)N=C1C1C=CC(Cl)=CC=1Cl Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	CHIR99021, also known as CT99021, is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM.