Salinomycin

Overview
Catalog #	bs-6925c-10mg-solid
Product Name	Salinomycin
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 751.0 Formula: C42 H70 O11 CAS Number: 53003-10-4 InChi Key: KQXDHUJYNAXLNZ-XQSDOZFQSA-N InChi: InChI=1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1 Smiles: C[C@]1(CC[C@]2(O1)O[C@]1(C=C[C@H]2O)O[C@H]([C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H]2O[C@H](CC[C@@H]2C)[C@@H](CC)C(O)=O)[C@@H](C)C[C@H]1C)[C@H]1CC[C@](O)(CC)[C@H](C)O1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The mechanism of action by which salinomycin kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore. Salinomycin could induce apoptosis of human cancer cells. Promising results from a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers.