GSK-25

Overview
Catalog #	bs-6874c-10mg-solid
Product Name	GSK-25
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 513.33 Formula: C24 H16 Cl2 F2 N6 O CAS Number: 874119-56-9 InChi Key: KZYAHEIPPAPADQ-UHFFFAOYSA-N InChi: InChI=1S/C24H16Cl2F2N6O/c1-11-21(24(35)32-19-6-13-10-30-34-18(13)9-17(19)28)22(15-3-2-14(25)8-16(15)27)33-23(31-11)12-4-5-29-20(26)7-12/h2-10,22H,1H3,(H,30,34)(H,31,33)(H,32,35) Smiles: CC1NC(=NC(C=1C(=O)NC1C=C2C=NNC2=CC=1F)C1C=CC(Cl)=CC=1F)C1=CC(Cl)=NC=C1 Purity: 98.0 Solubility: DMSO: 100 mg/mL (194.81 mM) Appearance: Solid Power. Shelf Life: 1.0 years
Description	GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 μM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 µM for CYP2C9, CYP2D6, CYP3A4, respectively).