Y-39983 HCl

Overview
Catalog #	bs-6858c-10mg-solid
Product Name	Y-39983 HCl
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 353.25 Formula: C16 H18 Cl2 N4 O CAS Number: 173897-44-4 InChi Key: CKFHAVRPVZNMGT-YQFADDPSSA-N InChi: InChI=1S/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/m1../s1 Smiles: Cl.Cl.C[C@@H](N)C1C=CC(=CC=1)C(=O)NC1C=CN=C2NC=CC=12 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	Y-39983, also known as Y-33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.