GSK429286A

Overview
Catalog #	bs-6852c-10mg-solid
Product Name	GSK429286A
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 432.37 Formula: C21 H16 F4 N4 O2 CAS Number: 864082-47-3 InChi Key: OLIIUAHHAZEXEX-UHFFFAOYSA-N InChi: InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31) Smiles: CC1NC(=O)CC(C=1C(=O)NC1C=C2C=NNC2=CC=1F)C1C=CC(=CC=1)C(F)(F)F Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.