K-252a

Overview
Catalog #	bs-6805c-10mg-solid
Product Name	K-252a
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 467.47 Formula: C27 H21 N3 O5 CAS Number: 99533-80-9 InChi Key: KOZFSFOOLUUIGY-SOLYNIJKSA-N InChi: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1 Smiles: C[C@]12O[C@H](C[C@]1(O)C(=O)OC)N1C3C(=C4C(CNC4=O)=C4C=3N2C2=CC=CC=C24)C2=CC=CC=C12 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	K-252a, also known as SF 2370, is an alkaloid isolated from Nocardiopisis bacteria. This staurosporine analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nmol/L).