Mitoxantrone

Overview
Catalog #	bs-6786c-10mg-solid
Product Name	Mitoxantrone
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 444.48 Formula: C22 H28 N4 O6 CAS Number: 65271-80-9 InChi Key: KKZJGLLVHKMTCM-UHFFFAOYSA-N InChi: InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2 Smiles: OC1=CC=C(O)C2=C1C(=O)C1C(=C(C=CC=1NCCNCCO)NCCNCCO)C2=O Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC50 = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.