PLX-4720

Overview
Catalog #	bs-6719c-10mg-solid
Product Name	PLX-4720
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 413.83 Formula: C17 H14 Cl F2 N3 O3 S CAS Number: 918505-84-7 InChi Key: YZDJQTHVDDOVHR-UHFFFAOYSA-N InChi: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) Smiles: CCCS(=O)(=O)NC1C=CC(F)=C(C(=O)C2=CNC3=NC=C(Cl)C=C23)C=1F Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	PLX-4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.