YM-201636

Overview
Catalog #	bs-6709c-10mg-solid
Product Name	YM-201636
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 467.48 Formula: C25 H21 N7 O3 CAS Number: 371942-69-7 InChi Key: YBPIBGNBHHGLEB-UHFFFAOYSA-N InChi: InChI=1S/C25H21N7O3/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17)22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32/h1-8,13-14H,9-12H2,(H2,26,28)(H,29,33) Smiles: NC1C=CC(=CN=1)C(=O)NC1C=C(C=CC=1)C1=NC2=C(OC3N=CC=CC=32)C(=N1)N1CCOCC1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	YM-201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3, 5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM-201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM-201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase.