SC-514

Overview
Catalog #	bs-6663c-10mg-solid
Product Name	SC-514
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 224.3 Formula: C9 H8 N2 O S2 CAS Number: 354812-17-2 InChi Key: BMUACLADCKCNKZ-UHFFFAOYSA-N InChi: InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12) Smiles: NC1C=C(SC=1C(N)=O)C1C=CSC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) that may target osteoclastogenesis. SC-514 dose-dependently inhibits RANKL-induced osteoclastogenesis and induced apoptosis and caspase 3 activation in RAW264.7 cells. Targeting IKKβ by SC-514 may be a potential treatment for osteoclast-related disorders such as osteoporosis and cancer-induced bone loss.