MLN2238

Overview
Catalog #	bs-6657c-10mg-solid
Product Name	MLN2238
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 361.03 Formula: C14 H19 B Cl2 N2 O4 CAS Number: 1072833-77-2 InChi Key: MXAYKZJJDUDWDS-LBPRGKRZSA-N InChi: InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 Smiles: CC(C)C[C@H](NC(=O)CNC(=O)C1C=C(Cl)C=CC=1Cl)B(O)O Purity: 98.0 Solubility: Soluble in DMSO, not soluble in water. Appearance: Solid Power. Shelf Life: 1.0 years
Description	MLN2238 is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL2238 is also .the biologically active form of MLN9708. MLN2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only MLN2238 alleviated osteolytic bone disease in the DP54-Luc model.