Rolapitant

Overview
Catalog #	bs-6632c-10mg-solid
Product Name	Rolapitant
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 500.48 Formula: C25 H26 F6 N2 O2 CAS Number: 552292-08-7 InChi Key: FIVSJYGQAIEMOC-ZGNKEGEESA-N InChi: InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1 Smiles: C[C@@H](OC[C@]1(CC[C@@]2(CN1)CCC(=O)N2)C1C=CC=CC=1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F Purity: 98.0 Solubility: Soluble in DMSO. Appearance: Solid Power. Shelf Life: 1.0 years
Description	Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV).