GW-627368X

Overview
Catalog #	bs-6630c-10mg-solid
Product Name	GW-627368X
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 544.62 Formula: C30 H28 N2 O6 S CAS Number: 439288-66-1 InChi Key: XREWXJVMYAXCJV-UHFFFAOYSA-N InChi: InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33) Smiles: CCOC1C2C=CC=CC=2C(OCC)=C2C=1CN(C1=CC=C(CC(=O)NS(=O)(=O)C3C=CC=CC=3)C=C1)C2=O Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	GW-627368X is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma. GW627368X will be a valuable tool to explore the role of the prostanoid EP4 receptor in many physiological and pathological settings.