WZB117

Overview
Catalog #	bs-6627c-10mg-solid
Product Name	WZB117
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 368.31 Formula: C20 H13 F O6 CAS Number: 1223397-11-2 InChi Key: FRSWCCBXIHFKKY-UHFFFAOYSA-N InChi: InChI=1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H Smiles: OC1C=C(C=CC=1)C(=O)OC1C(F)=CC=CC=1OC(=O)C1=CC(O)=CC=C1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	WZB117 is a potent Glut1 inhibitor. Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation. Blockade of GLUT1 by WZB117 resensitizes breast cancer cells to adriamycin. WZB117 is a prototype for further development of anticancer therapeutics targeting Glut1-mediated glucose transport and glucose metabolism.