GW806742X

Overview
Catalog #	bs-6623c-10mg-solid
Product Name	GW806742X
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 573.55 Formula: C25 H22 F3 N7 O4 S CAS Number: 579515-63-2 InChi Key: SNRUTMWCDZHKKM-UHFFFAOYSA-N InChi: InChI=1S/C25H22F3N7O4S/c1-35(22-13-14-30-23(34-22)31-18-3-2-4-21(15-18)40(29,37)38)19-9-5-16(6-10-19)32-24(36)33-17-7-11-20(12-8-17)39-25(26,27)28/h2-15H,1H3,(H2,29,37,38)(H,30,31,34)(H2,32,33,36) Smiles: CN(C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)OC(F)(F)F)C1C=CN=C(NC2C=CC=C(C=2)S(N)(=O)=O)N=1 Purity: 98.0 Solubility: Soluble in DMSO. Appearance: Solid Power. Shelf Life: 1.0 years
Description	GW806742X is a potent MLKL inhibitor, also a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and has anti-necroptosis activity. GW806742X has activity against VEGFR2. GW806742X blocked necroptosis and IL-33 release in vitro and reduced eosinophilia in Aspergillus fumigatus extract-induced asthma in vivo, an allergic inflammation model that is highly dependent on IL-33.