MI-2, Menin-MLL Inhibitor
| Overview | |
| Catalog # | bs-66046c-2mg-solid |
| Product Name | MI-2, Menin-MLL Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 375.55 Formula: C18 H25 N5 S2 CAS Number: 1271738-62-5 InChi Key: SRQYLNYQAPCPIR-UHFFFAOYSA-N InChi: InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3 Smiles: CCCC1=CC2C(=NC=NC=2S1)N1CCN(CC1)C1=NCC(C)(C)S1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | MI-2 is a potent and specific Menin-MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menin’s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein–mediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins. |
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