PIK-294

Overview
Catalog #	bs-6599c-10mg-solid
Product Name	PIK-294
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 489.53 Formula: C28 H23 N7 O2 CAS Number: 900185-02-6 InChi Key: WFSLJOPRIJSOJR-UHFFFAOYSA-N InChi: InChI=1S/C28H23N7O2/c1-16-7-3-4-12-21(16)35-22(32-20-11-5-8-17(2)23(20)28(35)37)14-34-27-24(26(29)30-15-31-27)25(33-34)18-9-6-10-19(36)13-18/h3-13,15,36H,14H2,1-2H3,(H2,29,30,31) Smiles: CC1C=CC=CC=1N1C(=O)C2C(=CC=CC=2C)N=C1CN1N=C(C2=C(N)N=CN=C12)C1=CC(O)=CC=C1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	PIK-294 is a highly selective inihibitor of the phosphoinositide 3-kinase (PI3K) p110δ with an IC50 value of 10 nM compared to IC50 values of 10 μM, 490 nM and 160 nM for PI3Kα/β/γ, respectively. PIK-294 has been used to help distinguish the unique roles of the various PI3-K isoforms. PIK-294 inhibited both chemokinetic and chemotactic CXCL8-induced migration.